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KMID : 0382320050250040143
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Environmental Mutagens and Carcinogens
2005 Volume.25 No. 4 p.143 ~ p.149
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Cyclooxygenase-2 Can Modulate ICAM-1 Expression in Aorta or Heart Tissues of Rats Treated with Synthetic Estrogen or Soy-isoflavones
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Kim YM
Lee SO/Park OJ
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Abstract
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The identification of COX-2 (cyclooxygenase-2) has led to potential novel insights on disease pathogenesis (atherosclerosis, cancer, Alzheimer’s disease) and the regulation of normal organ function. The present in vivo study with estrogen or soy-isoflavones has provided evidence for the association between COX-2 and ICAM-1 (Intercellular adhersion molecule-1). In the system of mature female rats, soyisoflavones exerted more pronounced effect on ICAM-1 inhibitory and COX-2 stimulatory effect than estrogen. In the system of ovariectomized estrogen deficient rats, the down-regulatory properties of soyisoflavones on ICAM-1 was less evident, whereas estrogen exerted the inhibitory activity. These results demonstrate that COX-2 limits adhersion molecule expression on rat aorta cells and suggest that COX-2 may play a protective role in cardiovascular system in mature female rats. Soy-isoflavones appear to have beneficial effect on vascular systems through modulation of ICAM-1 and COX-2, and these molecules appeared to be closely associated.
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KEYWORD
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